AGREEMENT BETWEEN THE GOVERNMENT OF THE REPUBLIC OF RWANDA AND THE AFRICAN MEDICINES AGENCY ON THE HEADQUARTERS OF THE AFRICAN MEDICINES AGENCY, SIGNED AT KIGALI, REPUBLIC OF RWANDA, ON 10 JUNE 2023

Ingingo ya mbere: Kwemeza burundu Article One: Ratification Article premier : Ratification Ingingo ya mbere: Kwemeza burundu Article One: Ratification Article premier : Ratification Amasezerano hagati ya Guverinoma ya Repubulika y’u Rwanda n’Ikigo Nyafurika cy’Imiti ku byerekeye Icyicaro cy’Ikigo Nyafurika cy’Imiti, yashyiriweho umukono i Kigali muri Repubulika y’u Rwanda, ku wa 10 Kamena 2023, ari ku mugereka w’iri teka, yemejwe atangiye gukurikizwa uko yakabaye. burundu kandi The Agreement between the Government of the Republic of Rwanda and the African Medicines Agency on the Headquarters of the African Medicines Agency, signed at Kigali, Republic of Rwanda, on 10 June 2023, annexed to this Order, is ratified and becomes fully effective. L’Accord entre le Gouvernement de la République du Rwanda et l’Agence Africaine des Médicaments sur le Siège de l’Agence Africaine des Médicaments, signé à Kigali en République du Rwanda, le 10 juin 2023, annexé au présent arrêté, est ratifié et sort son plein et entier effet. ARTICLE 1 OEFINITIONS For the purpose of this Agreement, and unless the context otherwise requires, the following terms and expressions shall have the meaning as stated hereunder: "Additional Protocol" means the Additional Protocol to the OAU General Convention on Privileges and lmmunities, adopted in July 1980 and acceded to by the Republic of Rwanda on 22 July 1985; "AiiA" means the African Medicines Agency; "AMA Headquarters and Premises" means areas designated as offices', laboratory, lands and any space, buildings, structures, equipment and other installations and facilities, as well as surrounding ground, occupied temporarily or permanently by the AMA located in the Host Country; "AMA Treaty" means the Treaty for the Establishment of the African Medicines Agency, adopted in February 2019 and entered into force on 05 November 2021 ; 'Agreement" means the present Headquarters Agreement between the African Medicines Agency and the Govemment of the Republic of Rwanda on the hosting of the AMA Headquarters and Premises; "Appropriate Authorities" means such national, local or other authority in the Host Country, as may be appropriate under the laws of the Host Country; "Archives" includes records, conespondence, documents, manuscripts, still and motion pictures, films and sound recordings, electronic records, belonging to or held by the AMA Headquarters and Premises in furtherance of its official functions; "Commission" means the African Union Commission established by the Constitutive Act of the African Union; "Chairperson" means the Chairperson of the African Union Commission, as defined by Article 20 of the Constitutive Act of the African Union; "Director General" refers to the head of the Secretariat of the AMA, as established by Article 24 ol lhe AMA Treaty; "Experts" mean individuals, other than officials, who owing to their special qualifications are recruited on a temporary basis to perform a specific assignment in the AMA Headquarters and Premises; 1 2 ( Official Gazette n° Special of 14/07/2023501 "General Convention" means the General Convention on the Privileges and lmmunities of the Organization of African Unity (OAU), adopted in July 1964 and ratified by the Republic of Rwanda on 18 June 1974; "Government" means the Govemment of the Republic of Rwanda; "Host Country" means the Republic of Rwanda; "Member of the AMA" refers to a member of the Governing Board and the Technical Committees who is appointed by the Conference of State Parties and the Governing Board, respectively, in accordance with Article 15 and 20 of the AMA Treaty; "Officials" means the Director General and all staff members of the AMA P4 rank and above, serving in the AMA Headquarters and Premises, inespective of nationality, except those recruited locally on hourly rates of pay, as defined in the Staff Regulations and Rules; "Organs of AMA" refers to the Conference of the State Parties, Goveming Board, Secretariat and Technical Committees of the AMA, as established by

Ingingo ya 2: Abayobozi bashinzwe gushyira mu bikorwa iri teka Article 2: Authorities responsible for the implementation of this Order Article 2 : Autorités chargées de l’exécution du présent arrêté Ingingo ya 2: Abayobozi bashinzwe gushyira mu bikorwa iri teka Article 2: Authorities responsible for the implementation of this Order Article 2 l’exécution du présent arrêté : Autorités chargées de Minisitiri w’Intebe, Minisitiri w’Ububanyi n’Amahanga n’Ubutwererane na Minisitiri w’Ubuzima bashinzwe gushyira mu bikorwa iri teka. The Prime Minister, the Minister of Foreign Affairs and International Cooperation and the Minister of Health are entrusted with the implementation of this Order. Le Premier Ministre, le Ministre des Affaires Étrangères et de la Coopération Internationale et le Ministre de la Santé sont chargés de l’exécution du présent arrêté. ARTICLE 2 PURPOSE AND SCOPE This Agreement shall regulate matters relating to or arising out of the establishment and functioning of the AMA Headquarters and Premises. lt shall inter alia provide for the long{erm stability and independence of the AMA and its relationship with the Host Country in the territory of the Host Country. Official Gazette n° Special of 14/07/2023502

Ingingo ya 3: Ingingo y’ururimi Article 3: Language provision Article 3 : Disposition linguistique Ingingo ya 3: Ingingo y’ururimi Article 3: Language provision Article 3 : Disposition linguistique Iri teka ryateguwe mu rurimi rw’Icyongereza. This Order was drafted in English. Le présent arrêté a été rédigé en anglais. ARTICLE 3 THE SEAT The Host Country shall provide, in accordance with the criteria for hosting of AU organs, secure, equipped and fumished permanent premises at its expense for the AMA Headquarters in Kigali, Rwanda.

Ingingo ya 4: Gutangira gukurikizwa Article 4: Entry into force Article 4 : Entrée en vigueur Official Gazette n° Special of 14/07/2023494 ITEKA RYA PEREZIDA Nº 042/01 RYO KU WA RYEMEZA 11/07/2023 BURUNDU AMASEZERANO HAGATI YA GUVERINOMA YA REPUBULIKA Y’U RWANDA N’IKIGO NYAFURIKA CY’IMITI KU BYEREKEYE ICYICARO CY’IKIGO NYAFURIKA CY’IMITI, I YASHYIRIWEHO KIGALI MURI REPUBULIKA Y’U RWANDA, KU WA 10 KAMENA 2023 UMUKONO BETWEEN RATIFYING PRESIDENTIAL ORDER Nº 042/01 OF THE 11/07/2023 AGREEMENT THE GOVERNMENT OF THE REPUBLIC OF AFRICAN AND RWANDA MEDICINES AGENCY ON THE HEADQUARTERS OF THE AFRICAN MEDICINES AGENCY, SIGNED AT KIGALI, REPUBLIC OF RWANDA, ON 10 JUNE 2023 THE ENTRE DE ARRÊTÉ PRÉSIDENTIEL Nº 042/01 DU 11/07/2023 PORTANT RATIFICATION LE DE L’ACCORD GOUVERNEMENT LA RÉPUBLIQUE DU RWANDA ET L’AGENCE DES MÉDICAMENTS SUR LE SIÈGE DE DES L’AGENCE MÉDICAMENTS, SIGNÉ À KIGALI EN RÉPUBLIQUE DU RWANDA, LE 10 JUIN 2023 AFRICAINE AFRICAINE Twebwe, KAGAME Paul, Perezida wa Repubulika; We, KAGAME Paul, President of the Republic; Nous, KAGAME Paul, Président de la République ; ku Itegeko Nshinga rya Dushingiye Repubulika y’u Rwanda ryo mu 2003 ryavuguruwe mu wa 2015, cyane cyane mu ngingo zaryo, iya 167 n’iya 168; Pursuant to the Constitution of the Republic of Rwanda of 2003 revised in 2015, especially in Articles 167 and 168; Vu la Constitution de la République du Rwanda de 2003 en 2015, spécialement en ses articles 167 et 168 ; révisée Tumaze gusuzuma Amasezerano hagati ya Guverinoma ya Repubulika y’u Rwanda n’Ikigo Nyafurika cy’Imiti ku byerekeye Icyicaro cy’Imiti, cy’Ikigo Nyafurika yashyiriweho umukono i Kigali muri Repubulika y’u Rwanda, ku wa 10 Kamena 2023; After consideration of the Agreement between the Government of the Republic of Rwanda and the African Medicines Agency on the Headquarters of the African Medicines Agency, signed at Kigali, Republic of Rwanda, on 10 June 2023; l’Accord entre Après examen de le Gouvernement de la République du Rwanda et l’Agence Africaine des Médicaments sur le Siège des Médicaments, signé à Kigali en République du Rwanda, le 10 juin 2023 ; l’Agence Africaine de Bisabwe n’Amahanga n’Ubutwererane; na Minisitiri w’Ububanyi On proposal by the Minister of Foreign Affairs and International Cooperation; Sur proposition du Ministre des Affaires Coopération de et Étrangères Internationale ; la Official Gazette n° Special of 14/07/2023495 Inama y’Abaminisitiri imaze kubisuzuma no kubyemeza; After consideration and approval by the Cabinet; Après examen et adoption par le Conseil des Ministres ; DUTEGETSE: DO ORDER: ARRÊTONS : Ingingo ya 4: Gutangira gukurikizwa Article 4: Entry into force Article 4 : Entrée en vigueur teka Iri ritangira gukurikizwa ku munsi ritangarijweho mu Igazeti ya Leta ya Repubulika y’u Rwanda. This Order comes into force on the date of its publication in the Official Gazette of the Republic of Rwanda. Le présent arrêté entre en vigueur le jour de sa publication au Journal Officiel de la République du Rwanda. Official Gazette n° Special of 14/07/2023496 Kigali, 11/07/2023 (sé) KAGAME Paul Perezida wa Repubulika President of the Republic Président de la République (sé) Dr NGIRENTE Edouard Minisitiri w’Intebe Prime Minister Premier Ministre Bibonywe kandi bishyizweho Ikirango cya Repubulika: Seen and sealed with the Seal of the Republic: Vu et scellé du Sceau de la République : (sé) Dr UGIRASHEBUJA Emmanuel Minisitiri w’Ubutabera akaba n’Intumwa Nkuru ya Leta Minister of Justice and Attorney General Ministre de la Justice et Garde des Sceaux Official Gazette n° Special of 14/07/2023497 HAGATI W’ITEKA RYA UMUGEREKA PEREZIDA Nº 042/01 RYO KU WA BURUNDU 11/07/2023 RYEMEZA AMASEZERANO YA GUVERINOMA YA REPUBULIKA Y’U RWANDA N’IKIGO NYAFURIKA CY’IMITI KU BYEREKEYE ICYICARO CY’IKIGO NYAFURIKA CY’IMITI, YASHYIRIWEHO I KIGALI MURI REPUBULIKA Y’U RWANDA, KU WA 10 KAMENA 2023 UMUKONO BETWEEN ANNEX TO PRESIDENTIAL ORDER Nº 042/01 OF 11/07/2023 RATIFYING THE AGREEMENT THE GOVERNMENT OF THE REPUBLIC OF AFRICAN AND RWANDA MEDICINES AGENCY ON THE HEADQUARTERS OF THE AFRICAN MEDICINES AGENCY, SIGNED AT KIGALI, REPUBLIC OF RWANDA, ON 10 JUNE 2023 THE DE ANNEXE À L’ARRÊTÉ PRÉSIDENTIEL Nº 042/01 DU 11/07/2023 PORTANT RATIFICATION L’ACCORD ENTRE LE GOUVERNEMENT DE LA RÉPUBLIQUE DU RWANDA ET L’AGENCE DES MÉDICAMENTS SUR LE SIÈGE DE DES L’AGENCE MÉDICAMENTS, SIGNÉ À KIGALI EN RÉPUBLIQUE DU RWANDA, LE 10 JUIN 2023 AFRICAINE AFRICAINE HAGATI AMASEZERANO YA GUVERINOMA YA REPUBULIKA Y’U RWANDA N’IKIGO NYAFURIKA CY’IMITI KU BYEREKEYE ICYICARO CY’IKIGO NYAFURIKA CY’IMITI, I YASHYIRIWEHO KIGALI MURI REPUBULIKA Y’U RWANDA, KU WA 10 KAMENA 2023 UMUKONO THE THE AGREEMENT BETWEEN THE GOVERNMENT OF THE REPUBLIC OF AFRICAN AND RWANDA MEDICINES AGENCY ON THE HEADQUARTERS OF THE AFRICAN MEDICINES AGENCY, SIGNED AT KIGALI, REPUBLIC OF RWANDA, ON 10 JUNE 2023 DE ENTRE LE L’ACCORD GOUVERNEMENT LA RÉPUBLIQUE DU RWANDA ET L’AGENCE DES MÉDICAMENTS SUR LE SIÈGE DE DES L’AGENCE MÉDICAMENTS, SIGNÉ À KIGALI EN RÉPUBLIQUE DU RWANDA, LE 10 JUIN 2023 AFRICAINE AFRICAINE Official Gazette n° Special of 14/07/2023498 African Union AGREEMENT BETWEEN THE GOVERNMENT OF THE REPUBLIC OF RWANDA AND THE AFRICAN MEDICINES AGENCY ON THE HEADQUARTERS OF THE AFRIGAN MEDICINES AGENCY $. Official Gazette n° Special of 14/07/2023499 PREAMBLE The Government of the Republic of Rwanda, hereinafter referred to as 'the Host Country' and the African Medicines Agency, represented by the African Union Commission, hereinafter refened to as 'the Commission', jointly referred to as the 'Parties' and in the singular as the 'Party': RECALLING the Treaty for the Establishment of the African Medicines Agency, adopted by the Assembly of Heads of State and Government of the African Union on '11 February 2019, which establishes the African Medicines Agency and its Secretariat; FURTHER RECALLING Decision EX.CUDec.1179(XLl) of July 2022, whereby the Executive Council upon delegated authority from the Assembly decided for the Republic of Rwanda to host the AMA Headquarters; CONSIDERING that the Republic of Rwanda is ready to host the AMA Headquarters and to grant it the privileges and immunities necessary for the execution of its mandate; WHEREAS through Decision EX.CUDec.229(Vll) of July 2005 the Executive Council adopted the 'Criteria for Hosting the AU Organs'; WHEREAS through Decision AHG/OAU/AEC/Dec.1(||) of June 1998 the Assembly of Heads of State and Govemment of the Organisation of African Unity granted officials of the Regional Economic Communities, African Economic Community, holders of the official travel document of these institutions, exemptions from visa requirements during travels within the AU Member States; WHEREAS the General Convention on the Privileges and lmmunities of the Organization of African Unity, adopted in Cairo, Egypt in July 1964, and the Additional Protocol to the OAU General Convention on Privileges and lmmunities, adopted in Freetown, Sierra Leone in July '1980, to which the Govemment of the Republic of Rwanda is a party, are rpso facto applicable to the hosting of the AMA Headquarters; AND WHEREAS the Republic of Rwanda intends to make appropriate arrangements to implement the particular elements contained in its offer to host the AMA Headquarters and ensure the availability of all the necessary facilities in the territory of the Republic of Rwanda to enable the AMA Headquarters to perform its functions; NOW THEREFORE, the Government of the Republic of Rwanda and the African Medicines Agency, represented by their duly authorized Representatives, have agreed as follows: 1 Official Gazette n° Special of 14/07/2023500 SEGTION ONE GENERAL PROVISIONS ARTICLE 4 LEGAL CAPACITY 1 2 1 2 The AMA shall possess such legal capacity as may be necessary in the tenitory of the Host Country to operate effectively for the exercise of its official functions and the fulfilment of its purposes. ln particular, the AMA shall have the capacity to: enter into contracts; b C acquire and dispose of immovable and movable property in accordance with the laws of the Host Country or such anangements as may be agreed upon with the Host Country; and institute legal proceedings and participate in legal process subject to the provisions of this Agreement. For the purpose of this Agreement, the Director General or the representative acting on his/her behalf shall represent the AMA within the territory of the Host Country. SECTION TWO PREMISES, FUNDS AND ASSETS

Article 10 of the AMA Treag; "Other Officials" means staff members of the AMA of P3 rank and below serving in the AMA Headquarters and Premises, inespective of nationality, except those recruited locally on hourly rates of pay, as defined in the Staff Regulations and Rules. "Secretariat" means the Secretariat of the AMA; "Sessions" refers to the statutory meetings of the Organs of the AMA, which include their Ordinary and Extraordinary sessions; "Union" means the African Union as established by the Constitutive Act of the African Union; "Vienna Convention" means the Vienna Convention on Diplomatic Relations, concluded in April 196'l and acceded to by the Republic of Rwanda on 24 April 1964. ARTICLE 10 PRIVILEGES AND IMMUNITIES The premises, property, funds and assets of the AMA shall be immune from legal process, search, requisition, confiscation, expropriation and any other form of interference or seizure whether by executive, administrative, judicial or legislative action, except in so far as in any particular case the Union has expressly waived its immunity, it being understood, however, that this waiver shall not extend to any acts of execution. The Director General and Officials of rank P4 and above shall have, in respect of themselves, their spouses and dependent children such diplomatic privileges and immunities as are accorded under the Vienna Convention, the General Convention and the Additional Protocol. Other fficials of rank P3 and below for the effective exercise of their functions shall enjoy within the Host Country privileges and immunities stipulated under the General Convention. Other privileges shall be accorded to the Officials that are commensurate with the privileges accorded to officials of comparable ranks of international organisations in the Host Country. The privileges and immunities provided for in this Agreement are granted to the officials in the interest of the AMA and not for the personal benelit of the individuals themselves. All Officials of the AMA who are residing in the Host Country shall be provided by the Government with a special identity card certifying the fact that they are officials of the AMA Headquarters and Premises enjoying the privileges and immunities specified in this Agreement, as well as the General Convention and the Additional Protocol. 7 1 J 4 5 - Official Gazette n° Special of 14/07/2023506 7 1 2 1 2 The AMA shall communicate to the Host Country the list of officials referred to above and shall revise the list from time to time as may be necessary. ARTICLE.Il PRIVILEGES AND IMMUNITIES OF GOVERNMENT REPRESENTATIVES AND OTHER MEMBERS OF ORGANS OF THE AMA Representatives of the Union's Member States and other members of organs of the AMA participating in the work of the AMA while performing their official functions in the Host Country or in any conference which may be convened by the AMA shall be entitled in the tenitory of the Host Country, while exercising their functions and during their travel to and from the Host Country, to the same privileges and immunities as are accorded to diplomatic envoys of comparable rank under international law. Representatives of non-African States accredited to the AMA, separately from representation to the Host Country, participating in the work of the AMA or in any conference which may be convened by the AMA, while exercising their functions and during their travel to and from the Host Country, shall be entitled to the same privileges and immunities as are accorded to diplomatic envoys of comparable rank under international law.

ARTICLE 5 PROVISION OF PREMISES, UTILITIES AND FACILITIES The Host Country shall at its expense provide secure, disability sensitive, dedicated, equipped and furnished permanent premises and structures which shall be exclusively occupied by AMA and its personnel in accordance with this Agreement and on the basis of the specifications provided by the AMA. The specified standards provided in Paragraph 1 above shall also apply, if the situation so requires, to the temporary building(s) that the Govemment may wish to provide to the AMA pending the construction or provision of the permanent structure(s). The Host Country shall provide the permanent laboratory within the first 2 years of submission of the technical requirements by the AMA. 4 The Host Country shall provide title deeds ol the AMA Headquarters and Premises, and their periodic renewal, if need be. 4 1 It Official Gazette n° Special of 14/07/2023503 5 6 7 8 o The Govemment shall provide a secured, equipped and furnished official residence for the Director General. The Govemment shall provide, at its expense, a security service for the first five (5) years of operation to the AMA Headquarters and Premises, and the residence of the Director General. The competent authorities shall exercise due diligence to ensure the security and protection of the AMA Headquarters and Premises, and to ensure that all the premises are easily accessible. With the view to meet the functional needs of the AMA Headquarters and Premises, the Host Country shall avail the AMA Headquarters and Premises at the most favourable rate the following: a. postal, telephone and internet services, electricity, water, gas, sewage, waste collection and disposal, fire protection, cleaning, maintenance and other facilities or services; b housing, hotel accommodation, hospitals, other health facilities, infrastructure including roads, schools, colleges, universities, hotels and airlines. Notwithstanding the provision of Paragraph 8 above, the Government shall ensure that the following services or facilities are availed free of charge for a period of five (5) years for both the AMA Headquarters and Premises and the residence of the Director General, in line with the Technical Annexes: electricity, water, internet connection, security, and service and maintenance fees. 10. Upon request of the Host Country, the Director General, or an official designated by him/her, shall make suitable arrangements to enable the duly authorized representatives of the appropriate public services to inspect, repair, maintain, reconstruct and relocate utilities, conduits, mains and sewers on the premises under conditions which shall not unreasonably disturb the carrying out of the functions of AMA Headquarters and Premises.

ARTICLE 6 ADDITIONAL FACILITIES PROVIDED BY THE HOST COUNTRY ln line with the official offer submitted by the Host Country, the Government shall provide additional facilities as provided in the Technical Annexes, which shall form an integral part of this Agreement.

ARTICLE 7 INV]OLABILITY OF THE PREMISES, ASSETS AND TRANSACTIONS 1 The AMA Headquarters and Premises, its funds, assets, transactions, archives and in general all documents, shall be inviolable. 5 \ & Official Gazette n° Special of 14/07/2023504 2 3 4 The competent authorities shall not enter the AMA Headquarters and Premises to perform any official duty, except with express consent or at the request of the Director General or an fficial designated by him/her. The inviolability provided for in Paragraph 1 above shall apply mutatrs mutandis to the residence of the Director General as well as the Officials. Nothing in this Agreement shall prevent the reasonable application by the appropriate authorities of measures for the protection of the premises against natural disaster, fire or any other emergency requiring prompt protective or remedial action.

ARTICLE 8 EXEMPTION FROM TAXES AND DUTIES 1 All assets, funds, incomes, transactions and other properties of the AMA in the territory of the Host Country shall be exempt from: a) direct taxes, which include, inter alia, income tax, capital tax, corporation tax as well as taxes levied by local and provincial authorities as well as other related exemptions and privileges; b) income tax for any income generated from commercial activities, upon condition that the income is used for purposes related to the mandate of AMA; c) customs duties and taxes in respect of goods, including publications and motor vehicles, whose import or export is necessary for the exercise of its official activities; d) Value-added tax paid on any goods and services which are necessary for official activities. Such claims for exemption will be made only in respect of goods or services supplied on a recurring basis or involving considerable expenditures; e) taxation on the rent or lease for any premises rented by the AMA and occupied by its services or personnel; and f) all compulsory contributions to any social security scheme of the Host Country. It is understood, however, that articles imported under the exemption provided in Paragraph 1 above will not be sold in the Host Country except under conditions agreed with the Appropriate Authorities. Officials of the AMA Headquarters and Premises, except nationals of the Host Country, shall have a right to import one or more shipments, within a period of twelve months of first taking up their appointment in the Host Country or a longer period of time in acmrdance with the law of the Host Country, free of duty and value-added tax exempted on: 6 ,{ 2 J 1 Official Gazette n° Special of 14/07/2023505 a) household and personal effects; b) one ('l) motor vehicle by unmarried officials while those who are married shall be allowed to import two (2) motor vehicles. Replacement of such motor vehicles may be done free of duty and exempted of value added tax only after three (3) years or where the vehicle is written off due to accident, fire or theft. ART]CLE 9 FREEDOM OF FINANCIAL ASSETS FROI/i RESTRICTION The AMA shall freely purchase any currencies through authorized channels and hold and dispose of them, transfer its funds to or from the Host Country, and operate accounts in any cunency. SECTION THREE PRIVILEGES AND IMMUNITIES

ARTICLE 12 PERSONS ON MISSION FOR THE AFRICAN MEDICINES AGENCY Persons performing missions on behalf of the AMA shall enjoy the privileges, immunities and facilities provided by the General Convention and accorded as necessary for the independent exercise of their functions during the period of their mission to the Host Country. The privileges and immunities granted to persons performing missions for the AMA in this Agreement are in the interest of the AMA and not for personal benefit.

ARTICLE 13 PRIVILEGES AND IMMUNITIES OF EXPERTS AND CONSULTANTS Experts and consultants, except Host Country's nationals and permanent residents, shall be accorded such immunities and privileges as are necessary for the proper exercise of their functions during the period of their mission and, in particular, they shall: a) be immune from personal arrest or detention; b) enjoy inviolability for all papers and documents and records in whatever form including computer-generated documents; c) be accorded the same facilities in respect of currency or exchange restrictions as are accorded to representatives of foreign governments on temporary official missions; \ 8 Official Gazette n° Special of 14/07/2023507 d) be accorded the same protection and repatriation facilities with respect to themselves, their spouses and dependent relatives and other members of the family as are accorded in times of intemational crises or national emergencies to diplomatic envoys; e) be immune from any legal process in respect of words spoken or written and all acts performed by them in their official capacity; f) for the purposes of communicating with the AMA Headquarters and Premises, have the right to receive papers and conespondence by courier or in sealed bags; and S) enjoy the same immunities and facilities in respect of their personal baggage as are accorded to diplomatic envoys.

ARTICLE 14 WAIVER OF IMMUNITY 1 2 3 4 1 2 Without prejudice to the privileges and immunities accorded by this Agreement, it is the duty of all persons enjoying such privileges and immunities to observe the laws and regulations of the Host Country. Should the Host Country consider that an abuse of a privilege or immunity conferred by this agreement has occurred, the Director General shall, upon request, consult with the appropriate authorities to determine whether any such abuse has occurred. lf such consultations fail to achieve a result satisfactory to one or both Parties, the mafter shall be determined by the Chairperson in accordance with the General Convention and the Staff Regulations and Rules. On receipt of a written request to waive immunity, the Chairperson, without prejudice to the interests of the Union, has the right to waive the immunity granted to an official, if in his/her opinion, the immunity would impede the course of justice. No personal anest, detention, search, prohibition of movement and or immigration restriction, alien registration, fingerprinting, violability of premises, residence, chattel or vessel shall be effected against any staff of the AMA and the Union prior to the written grant of waiver from the Chairperson or the Executive Council of the Union as the case may be.

ARTICLE 15 FLAG, EMBLEM AND MARKINGS The Host Country recognizes the right of the AMA to display within the Host Country its flag, the flag of the Union and Union's Member States on its premises, vehicles, vessels and as otherwise decided by the Director General and the Govemment. Vehicles, vessels and aircraft of the AMA may carry the emblem, flag and markings, which shall be notified to the Host Country. 9 t 8. Official Gazette n° Special of 14/07/2023508 SECTION FOUR VISAS, PERMITS AND OTHER DOCUMENTS

ARTICLE 16 LAISSEZ.PASSER 1 2 ,| 2 J 1 2 The Host Country shall recognize and accept the Union's laissez-passer or a travel document issued by the Union to its officials as valid travel documents. As such, holders of the AU laissez-passer shall be exempt from visa requirements. Holders of the official travel document of the Regional Economic Communities shall also be exempt from visa requirements during travels to the Host Country related to AMA affairs.

ARTICLE 17 VISA" ACCESS, TRANSIT AND RESIDENCE The Host Country shall take all necessary measures to facilitate the arrival to and departure from the Host Country, of the Officials, their spouses and dependents, invited experts, officials of the Union and other persons invited for ofiicial business in accordance with the existing Host Country's regulations. Subject to Paragraph 1 above, the Host Country shall issue visas, work permits and dependent passes gratis for Officials, their spouses and dependents, invited experts and officials of the Union in accordance with the existing Host Country's regulations. Applications for visas, where required, shall be processed by the Host Country as promptly as possible and granted free of charge. SECT]ON FIVE COMMUNICATION FACILITIES FOR THE FUNCTIONING OF THE ORGANIZATION

ARTICLE 18 COMMUNICATIONS The AMA shall enjoy, in respect of its official communications, treatment not less favourable than that accorded by the Host Country to international organizations in matters of cablegrams, telephotos, telephone, telegraph, telex, telefax, email, satellite communication and other modes of communication. The AMA shall have the right to use codes and to dispatch and receive conespondence and other materials by courier or in sealed bags, which shall have the same privileges and immunities as diplomatic muriers and bags. 10 Official Gazette n° Special of 14/07/2023509 5 4 1 2 1 2 J The AMA shall have the right to operate a radio station or such additional broadcasting and other communications facilities under the Union's registered frequencies oriand those allocated by the Host Country, within and outside the Host Country. All official communications directed to the AMA Headquarters and Premises, or to any of its Officials, and all outward official communications, by whatever means or in whatever form transmitted, shall be immune from censorship and from any other form of interference.

ARTICLE 19 PUBLICATION The AMA shall have the right to publish within the tenitory of the Host Country in conformity with this Agreement any information or other material relating to its functions. The AMA shall have the right to establish and operate research, documentation and other technical facilities in the Host Country and shall have the right to install and operate them at the AMA Headquarters and Premises.

ARTICLE 20 TRANSPORTATION Aircraft operated by or for the AMA shall be exempt from all charges, except those for actual service rendered, and from fees or taxes incidental to the landing at, parking on or taking off from an aerodrome in the Host Country. Any vessel operated by or for the AMA shall be exempt from all charges, except those for actual service rendered, and from fees or taxes incidental to the docking at, or sailing away from any dock in the Host Country. For its official purposes, the AMA shall be entitled to use transportation operated by the Host Country at the same rates and treatment as may be granted to resident diplomatic missions or any other international organization. SECTION SIX APPLICABLE LAWS

ARTICLE 21 APPLICATION OF THE GENERAL CONVENTION, THE ADDITIONAL PROTOCOL AND THE VIENNA CONVENTION The General Convention, the Additional Protocol and the Vienna Convention shall be applicable to the AMA, its property, funds and assets, the AMA Headquarters and Premises, fficials and persons performing missions on behalf of the AMA. \ 11 & Official Gazette n° Special of 14/07/2023510 1 2 J 4 1 2 J 1

ARTICLE 22 APPLICATION OF THE LAWS OF THE HOST COUNTRY Except as otheruise provided in this Agreement or in the General Convention, the laws and regulations of the Host Country shall not apply on the AMA Headquarters and Premises. The AMA shall have the power to make regulations operative on the AMA Headquarters and Premises for the purpose of establishing therein the conditions in all respects necessary for the full execution of its functions. The AMA shall promptly inform the competent authorities of regulations thus enacted in accordance with Paragraph 2 above. No law or regulation of the Host Country which is inconsistent with a regulation of the AMA shall, to the extent of such inconsistency, be applicable within the AMA Headquarters and Premises. SECTION SEVEN FINAL PROVISIONS

ARTICLE 23 LIAISON FUNGTIONS AND OBLIGATIONS OF THE PARTIES The Host Country shall take all necessary measures to facilitate the work of the AMA Headquarters and Premises with the Appropriate Authorities and intemational organizations duly accredited within the jurisdiction of the Host Country. The Host Country shall designate one or more representatives within the Ministry of Foreign Affairs and lnternational Cooperation for the purpose of liaison with the AMA. The AMA shall cooperate at all times with the Appropriate Authorities to facilitate the proper administration of justice, secure the observance of police regulations and prevent the occurrence of any abuse in connection with the privileges and immunities granted in the interest of the functions and effective functioning of the AMA Headquarters and Premises, and in accordance with this Agreement.

ARTICLE 24 SETTLEMENT OF DISPUTES Any dispute arising out of or in connection with this Agreement, including any question regarding its validity or termination shall be resolved through negotiations or, failing that, shall be referred to or resolved by arbitration under the UNCITRAL Arbitration Rules. \ 1,2 & Official Gazette n° Special of 14/07/2023511 2 J 4 1 J 4 1 2 The number of arbitrators shall be three (3). Each Party shall appoint one arbitrator. The two (2) arbitrators thus appointed shall choose the third arbitrator who shall act as the presiding arbitrator of the arbitral tribunal. lf within thirty (30) days after the appointment of the second arbitrator the two arbitrators have not agreed on the choice of the presiding arbitrator, the presiding arbitrator shall be appointed by any Arbihation Centre based in Africa. The seat or legal place of arbitration shall be AMA Headquarters and Premises or the Headquarters of the Union or any other place where the Union has its organsfinstitutions/offices. The AMA and the Union shall provide hearing space free of charge. The working language of the arbitral proceedings shall be thaVthose of the Union to be determined jointly by the Parties.

ARTICLE 25 INTERPRETATION The provisions of this Agreement and any supplementary agreement shall be interpreted in accordance with international laws and construed in the light of its primary purpose to enable the AMA in the Host Country to discharge its responsibilities and fulfill its purposes fully and efficiently. The Parties, through consultation and negotiation, shall settle any relevant matter for which no provision is made in this Agreement. Each Party shall give full and sympathetic consideration to any proposal advanced by the other Party under this Article. This Agreement shall be supplemented by the Offers made by the Host Country as provided for under the Technical Annexes on the Expression of lnterest of the Republic of Rwanda to host the AMA Headquarters and Premises. The Parties may conclude additional technical annexes, supplementary agreements or arrangements to facilitate the hosting of the AMA Headquarters and Premises, and these shall form an integral part of this Agreement.

ARTICLE 26 AMENDMENTS This Agreement may be amended by mutual consent at any time at the request of either Party. This shall be made by a joint written agreement between the AMA and the Host Country. The Pa(ies shall jointly examine and agree to the appropriate changes to be made to the provisions of this Agreement. 13 Official Gazette n° Special of 14/07/2023512 Technical Annex I - Additional Offers and lncentives by the Host Country of the AMA Headquarters and Premises Submitted as response to the questionnaire on 28February202i2 Rwanda offers the following pledges towards the setting up of the AMA Secretariat and Laboratory: a. To sign the Host Country Agreement within 1 month of selection and to work closely with the AU Commission to ensure that the AMA is operational within 6 months. b. To offer the option to identify and purchase land and develop new premises to accommodate AMA's headquarters and laboratory facilities. This will be done in close collaboration with AMA'S team to ensure that construction and facilities are in accordance with AMA'S specific norms and standards. c. To provide 2 focal persons, one from MINAFFET and another from Rwandan FDS for liaison purposes. d. To offer AMA staff special interest rates on loans e. To offer AMA Staff and their families local tourism rates f. To allow spouses of AMA's staff members to engage in gainful ventures and facilitate access to work permits, which will ensure utilization of spouses' skills. Revisod lncen$ves submltted on 8 |tarch202j2 Please refer to the annexed table which has costed elements for one-time payment and for a 5 year period. Revised Ofrer3 submatted during aise$rnsnt mbsion on 9 llarch 202 The following are additions the incentives offered by the Govemment Rwanda towards the setting up of the AMA Headquarters and Laboratory: a. To provide partitioning and equipment for the Alliance lnvestment Plaza according to AMA requirements and needs. b. To cover electricity, water, intemet connection, security, and service and maintenance fees for both the office and DG's residence, for a period of 5 years. c. To purchase land, construct, and equip new AMA'S laboratory facilities. This will be done in close collaboration with AMAs team to ensure that facilities are In accordance wilh AMA'S specific requirements and standards. The assessment team was shown 2 options and provided with site plans of both plots. d. To provide a team of 10 seconded staff in key areas such as procurement, lCT, finance/accounting, HR, protocol, and a regulatory expert, paid by the Govemment of Rwanda for a period of 5 years. e. To purchase a modern SUV vehicle for the DG of AMA. f. To hire a personal driver for the DG of AMA for a period of 5 years. g. To purchase 10 SUV vehicles for AMA staff. h. To provide conference facilities with all amenities (meals, intemet, etc.) for AMA meetings, conferences, and events for a period of 5 years. i. To provide the DG of the AMA+2 with a s-year golf membership at Kigali Golf Club and offer corporate rates to the rest of the AMA staff. j. To provide the DG of AMA and I members of AMA management team, memberships at a sporting facility for a period of 5 years. k. To purchase 100 computers including laptops and desktops for AMA staff. L To purchase 10 printers for the AMA headquarters. m. To purchase security equipment, including a luggage scanner, metal detector, and vehicle x-ray. 15 \ * Official Gazette n° Special of 14/07/2023513 TABLE 1 - REVISED ADDITIONAL INCENTIVES SUBMITTED ON 8 MARCH 2022 (COSTED ELEIIENTS FOR ONE-TIME PAYIIENT AND FOR A 5 YEAR PERlOD) q rfti*'.Ic tu raoa ,acGD ,tct tn fJi lor Iu (3 YtArtg I (_tr r rc t cosl of tu[orttc PAiTIN{){ING AXO'URHITUIT LATT INSTALLAIIO'T warft arao fttcTnrcrTY lxTtrNtT rtEs stRvlct rtts MAlltItr{axct 'tCURlrY cost ot vnt^ tuilltlutf arD f oulPtrtt{T rtt arfo ftfcTRroTY lNTrntifr Sfnvrcf r tts fCI.tR'TY ,\rvl i, I i\,,, 'r ,_\ I , afxxnoiat BtNtrtIS I ruV VtHrrf lDl6l to vtmctrt tor 'Iarr 6OtI MtMSfRtBlP (OG.2l MaMtfrsiirt ?o 5.orT gacrtrtY (oc+9l lm Comprre rr lO P.l lr! t 2 I a s 6 7 t 9 to lr It l:t la !3 t6 t, IE t9 2(, l1 2:' 2a 15 26 2' Orr'rtlon lOtA l .iF,r or+tllna aotl 3 F..t 3 y..6 5 yar6 ttn 6 5 5 yaa6 5 tat 5 ycr6 S terr! 3 2 9.f{Xr, t.7 61 2,/ro1 3 s s ..6r?.GCO Pn {fr rd 1 16 I c I Official Gazette n° Special of 14/07/2023514 CONSOLIDATED LIST OF ADDITIONAL OFFERS AND INCENTIVES FOR AIIIA, WHERE APPLICABLE, wlTH THE MOST FAVORABLE CONDITIONS: 1 2 J 4 5 o 7 8 I To provide partitioning and equipment for the Alliance lnvestment Plaza according to AMA requirements and needs; To cover electricity, water, internet connection, security, and service and maintenance fees for both the office and DG's residence, for a period of 5 years; To purchase land, construct, and equip new AMA'S laboratory facilities. This will be done in close collaboration with AMA'S team to ensure that facilities are in accordance with AMA's specific requirements and standards. The assessmenl team was shown 2 options and provided with site plans of both plots; To purchase a modem SUV vehicle for the DG of AMA; To purchase 10 SUV vehicles for AMA staff; To provide conference facilities with all amenities (meals, internet, etc.) for AMA meetings, conferences, and events for a period of 5 years; To purchase 100 computers including laptops and desktops for AMA staff; To purchase 10 printers for the AMA headquarters; To purchase security equipment, including a luggage scanner, metal detector, and vehicle x-ray; 10. To provide 2 focal persons, one from MINAFFET and another from Rwandan FDS for liaison purposes; 1 1 . To provide the DG of the AMA+2 with a s-year golf membership at Kigali Golf Club and offer corporate rates to the rest of the AMA staff; 12. To provide the DG of AMA and I members of AMA management team, memberships at a sporting facility for a period of 5 years; 13. To offer AMA staff special interest rates on loans; 14. To offer AMA Staff and their families local tourism rates; 15. To allow spouses of AMA's staff members to engage in gainful ventures and facilitate access to work permits, which will ensure utilization of spouses' skills; and 16. Under (or subject to) the terms and conditions agreed on by the Govemment of Rwanda and AMA to: a) provide a team of 10 seconded staff in key areas such as procurement, lCT, finance/accounting, HR, protocol, and a regulatory expert, paid by the Government of Rwanda for a period of 5 years; b) hire a personal driver for the DG of AMA for a period of 5 years 1 77 & Official Gazette n° Special of 14/07/2023515

ARTICLE 27 REPORTING 1 2 1 2 J The Parties shall keep each other informed of all relevant activities pertaining to this collaboration and shall hold consultations as appropriate, in order to evaluate the progress in the implementation of this Agreement and to revise and develop new plans for cunent or prospeclive activities. The AMA shall report on the implementation of this Agreement to the Conference of State Parties through the Governing Board.

ARTICLE 28 ENTRY INTO FORCE AND TERMINATION This Agreement shall be signed by the duly authorized representatives of the Host Country and the AMA. lt will enter into force upon the deposit of the instrument of ratification by the competent authorities of the Host Country. This Agreement and any supplementary agreement entered into by the Host Country and the AMA within the scope of its terms of reference, shall cease to be in force six (6) months after either of the Parties shall have given notice in writing to the other of its decision to terminate the Agreement and any other supplementary agreement. Relevant provisions of this Agreement shall continue to be applied after its termination for the time reasonably required for the settlement of the affairs of the AMA and the disposal of property in the Host Country as well as for the repatriation of personnel from the territory of the Host Country as the case may be. lN WITNESS WHEREOF, the undersigned representative duly authorized by the Govemment of the Republic of Rwanda and the African Union Commission respectively, have on behalf of Parties, signed this Agreement. DONE in English language, in duplicate, at Kigali, Republic of Rwanda on the 't Oth day of June Two thousand and Twenty-Three. Forthe Government ofthe Republic Forthe African Medicines Agency of Rwan a Dr. Sabin N nzrmana Minister of Health Amb. Minata Samat6 Cessouma Commissioner for Health, Humanitarian Affairs and Social Development African Union Commission \ 1,4 Official Gazette n° Special of 14/07/2023516 Bibonywe kugira ngo bishyirwe ku mugereka w’Iteka rya Perezida n° 042/01 ryo ku wa 11/07/2023 ryemeza burundu Amasezerano hagati ya Guverinoma ya Repubulika y’u Rwanda n’Ikigo Nyafurika cy’Imiti ku byerekeye Icyicaro cy’Ikigo Nyafurika cy’Imiti, yashyiriweho umukono i Kigali muri Repubulika y’u Rwanda, ku wa 10 Kamena 2023 Seen to be annexed to Presidential Order n° 042/01 of 11/07/2023 ratifying the Agreement between the Government of the Republic of Rwanda and the African Medicines Agency on the Headquarters of the African Medicines Agency, signed at Kigali, Republic of Rwanda, on 10 June 2023 du de 11/07/2023 l’Accord Vu pour être annexé à l’Arrêté Présidentiel portant n° 042/01 ratification le Gouvernement de la République du l’Agence Africaine des Rwanda Médicaments sur le Siège de l’Agence Africaine des Médicaments, signé à Kigali en République du Rwanda, le 10 juin 2023 entre et Official Gazette n° Special of 14/07/2023517 Kigali, 11/07/2023 (sé) KAGAME Paul Perezida wa Repubulika President of the Republic Président de la République (sé) Dr NGIRENTE Edouard Minisitiri w’Intebe Prime Minister Premier Ministre Bibonywe kandi bishyizweho Ikirango cya Repubulika: Seen and sealed with the Seal of the Republic: Vu et scellé du Sceau de la République : (sé) Dr UGIRASHEBUJA Emmanuel Minisitiri w’Ubutabera akaba n’Intumwa Nkuru ya Leta Minister of Justice and Attorney General Ministre de la Justice et Garde des Sceaux Official Gazette n° Special of 14/07/2023518